Need for catecholamines No Yes
Lactate > 2 mmol/L No Yes
Urine production < 1ml/kg/h No Yes
Increasing systemic inflammatory response No Yes

Platelet count (μg/ml)< 90.000 No Yes
Any signs of coagulopathy or disseminated intravasal coagulopathy (DIC) No Yes

Temperature > 38°C No Yes

Brain swelling, GCS ≤8 No Yes
Lung function; PaO2/FiO2 350 – 400 < 350
Abdominal Compartment, Ileus No Yes
Rhabdomyolysis, Soft tissue swelling, Blisters, Soft Tissue Defects No Yes